Flexible tubing occlusion assembly

ABSTRACT

An occlusion assembly for compressing a pair of collapsible tubes comprises a frame comprising a tubing guide configured for positioning the collapsible tube. The occlusion assembly also comprises a tubing occluder mounted to the frame with an occluding member constructed and positioned to controllably occlude or release occlusion of the collapsible tube. A door mounted to the frame is positioned to cover at least a portion of the collapsible tube and tubing occluder when closed and provide user access when open. The assembly includes a retainer mechanism engaged by the door when the door is closed to permit operation of the tubing occluder when the door is closed and retain the tubing occluder in a non-occluding configuration when the door is opened.

RELATED APPLICATIONS

This application is a division of U.S. patent application Ser. No.15/181,234, filed Jun. 13, 2016, and issued on Jul. 11, 2017, as U.S.Pat. No. 9,700,711, which is a division of U.S. patent application Ser.No. 13/480,236, filed May 24, 2012, and issued on Jun. 14, 2016, as U.S.Pat. No. 9,364,655, all of which are incorporated herein by reference intheir entireties.

FIELD

The present specification generally describes occluder devices foroccluding flexible tubing, particularly in medical infusion systems.

BACKGROUND

Medical devices, such as hemodialysis machines, medical infusion pumps,plasmapheresis devices, and the like, often require the use of tubing tofacilitate the flow of fluids, e.g., to or from a patient using suchdevice. Such tubing in many instances is made of a flexible material andis designed to be collapsible in order to facilitate peristaltic pumpingand/or occlusion of fluid flow via collapse of the lumen of the flexibletubing. A variety of tubing clamps and tubing occlusion devices areknown. Certain of these devices can be integrated into a medicalinfusion device and automatically controlled. In certain applications,medical infusion devices must handle fluids that include ingredientsthat, due to leakage or other factors that may lead to presence of thefluid on the external surfaces of the tubing, can become sticky and orresult in fouling or failure of certain conventional tubing occluderdesigns.

SUMMARY

Described herein are occlusion assemblies configured to facilitate theopening and closing by occlusion of flexible tubing. In particularembodiments, the occlusion assemblies are associated with or form partof a medical infusion device, such as a hemodialysis device, peritonealdialysis device, plasmapheresis device, etc., and may be controllablyand automatically operated to facilitate fluid handling by such devices.The occlusion assemblies may be designed to position and immobilized thetubing and may include a frame or other support feature providing tubingguides and/or configured for attachment to or integration with a fluidhandling assembly of a device of which they are part or with which theyare used. The occlusion assemblies comprise a tubing occluder, which maybe a mechanism constructed and positioned to apply a force to thetube(s) associated with the occlusion assembly to occlude the tubes andto release the force to allow the tubes to open for fluid flow. Theocclusion assemblies and tubing occluders may be configured to include asingle tube in certain cases, and in other cases to occlude multipletubes, whether an odd number of tubes or an even number of tubes.Certain occlusion assemblies are specifically configured for occludingone or more pairs of tubes and may include tubing occluders having aseparate occluding member for occluding each of the pair of collapsibletubes. The occlusion assemblies may include automatic actuators foroperating the tubing occluders, and in certain cases also include amanual actuator to provide an override function. The occlusionassemblies may include a door designed and positioned to cover at leasta portion of the tubes to be occluded and tubing occluder mechanism.Such occlusion assemblies may include safety features, for example, toprevent a release of occlusion force on the tubing when the door is notin a closed position and/or convenience features, for example a retainermechanism to hold the tube occluder in a non-occluding position when thedoor is open with the tube occluder in the non-occluding position.

In one aspect, a variety of occlusion assemblies for occluding at leastone collapsible tube of a medical infusion device are described. Incertain embodiments, the occlusion assembly is configured for occludingat least one pair of collapsible tubes and comprises, for each pair ofcollapsible tubes, a first occluding member and a second occludingmember, the first occluding member positioned adjacent to a firstcollapsible tube of the pair and the second occluding member positionedadjacent to a second collapsible to the pair, when the tubes areinstalled in the occlusion assembly for operation. The first occludingmember and the second occluding member are further positioned adjacentfrom each other such that a space is defined between them. These spaceis on an opposite side of each occluding member then is the collapsibletube to which it is adjacent. The occlusion assembly further comprises aspreader positioned within the space between the occluding members andmovable from a first position to a second position, wherein movementfrom the first position to the second position causes the spreader toforce at least a portion of the first and second occluding members tomove apart from each other to increase the size of the space betweenthem and forced a tube-contacting portion of each occluding memberagainst the collapsible tube to which it is adjacent to occlude thecollapsible tube. The occlusion assembly further comprises at least oneactuator constructed and positioned to move the spreader between thefirst and second positions.

In certain embodiments the occlusion assembly is configured foroccluding at least one collapsible tube and comprises a frame comprisinga tubing guide configured for positioning the collapsible tube, a tubingoccluder mounted to the frame and comprising an occluding memberconstructed and positioned to controllably occlude or release occlusionof the collapsible tube, a door hingeably mounted to the frame andpositioned to cover at least a portion of the collapsible tube andtubing occluder when in a closed position and to provide user access tothe collapsible tube when in an open position, and a switch configuredand positioned to detect when the door is in a closed position and topermit operation of the tubing occluder to release occlusion of thecollapsible tube only when the door is in the closed position.

In certain embodiments and occlusion assembly for collapsing at leastone collapsible tube comprises a tubing occluder comprising an occludingmember constructed and positioned to controllably occlude or releaseocclusion of the collapsible tube, and automatic actuator operativelycoupled to the tubing occluder to cause essentially linear motion of atleast a portion of the tubing occluder to cause the occluding member tomove from an occluding position to a non-occluding position, and anoverride mechanism operatively coupled to the tubing occluder to causeessentially linear motion of at least a portion of the tubing occluderto cause the occluding member to move from an occluding position to anon-occluding position upon manual operation of the override mechanismby a user.

In certain embodiments, and occlusion assembly for occluding at leastone collapsible tube comprises a frame comprising a tubing guideconfigured for positioning the collapsible tube, a tubing occludermounted to the frame and comprising an occluding member constructed andpositioned to controllably occlude or release occlusion of thecollapsible tube, a door hindgeably mounted to the frame and positionedto cover at least a portion of the collapsible tube and tubing occluderwhen in a closed position and to provide user access to the collapsibletube when in an open position, and a retainer mechanism engaged by thedoor when the door is in the closed position and configured to permitoperation of the tubing occluder to occlude or release occlusion of thecollapsible tube when the door is in the closed position and configuredto engage and retain the tubing occluder in a non-occludingconfiguration when the door is opened while the tubing occluder ispositioned in the non-occluding configuration.

In another aspect a method of operating an occlusion assembly foroccluding at least one pair of collapsible tubes of a medical infusiondevices disclosed. In one embodiment, the method involves moving aspreader of the occlusion assembly from a first position to a secondposition, wherein the spreader is positioned within a space definedbetween a first occluding member and a second occluding member to causethe spreader to force at least a portion of the first and secondoccluding members to move apart from each other to increase the size ofthe space between them and force a tube-contacting portion of eachoccluding member against a collapsible tube to which it is adjacent toocclude the collapsible tube.

Other advantages and novel features of the present invention will becomeapparent from the following detailed description of various non-limitingembodiments when considered in conjunction with the accompanyingfigures. In cases where the present specification and a documentincorporated by reference include conflicting and/or inconsistentdisclosure, the present specification shall control.

BRIEF DESCRIPTION OF THE DRAWINGS

The accompanying drawings are schematic are not intended to be drawn toscale. In the figures, each identical, or substantially similarcomponent that is illustrated in various figures is typicallyrepresented by a single numeral or notation. For purposes of clarity,not every component is labeled in every figure, nor is every componentof each embodiment of the invention shown where illustration is notnecessary to allow those of ordinary skill in the art to understand theinvention. In the drawings:

FIG. 1 shows an exploded, perspective view of an occlusion assembly froma front angle in accordance with an embodiment of the presentdisclosure;

FIG. 2 shows an exploded, perspective view of the occlusion assembly ofFIG. 1 from a back angle;

FIG. 3 shows a front, perspective view of the occlusion assembly of FIG.1 with the door open and the button pressed to illustrate loading of atube;

FIG. 4 shows a close-up perspective view of the occlusion assembly ofFIG. 1, showing the door engaging a switch when the door is closed;

FIG. 5 shows the front of the occlusion assembly of FIG. 1 without thedoor and frame to illustrate the arms fully occluding flexible tubes;

FIG. 6 shows the front of the occlusion assembly of FIG. 1 without thedoor and frame to illustrate the arms in a non-occluding position;

FIG. 7 is a rear/top perspective view of the occlusion assembly of FIG.1 with an actuator arm in a fully retracted position;

FIG. 8 is a rear perspective view of the occlusion assembly of FIG. 1with an actuator arm in a fully extended position;

FIG. 9 shows a side perspective view of several working parts of theocclusion assembly of FIG. 1 in a non-occluding state;

FIG. 10 shows a side perspective view of several working parts of theocclusion assembly of FIG. 1 in an occluding state;

FIG. 11 shows a side, cross-sectional view of an actuator of theocclusion assembly of FIG. 1, illustrating a location for a main springfor the assembly; and

FIG. 12 shows the occlusion assembly of FIG. 1 mounted in a front panelassembly of a hemodialysis apparatus in accordance with an embodiment ofthe present disclosure.

DETAILED DESCRIPTION

In accordance with one aspect of the disclosed invention, an occlusionassembly for compressing at least one flexible tube, for example a pairof flexible tubes is described. The occlusion assembly includes a tubeoccluder comprising a mechanism configured to occlude fluid flow withinone or more flexible tubes, and in certain embodiments one or more pairsof flexible tubes. In certain embodiments, the tube occluder of theocclusion assembly comprises at least one occluding member, and in aspecific embodiment comprises an occluding member for each section oftubing placed within the assembly. In certain such embodiments, eachoccluding member is pressed or otherwise forced or urged into anoccluding position by an element that slides along a side of theoccluding member, causing the occluding member to pivot at its proximalend and to translate toward the tubing at its distal end. In anembodiment, the element is positioned between two occluding members andacts to spread the distal ends of the occluding members away from eachother as they press against their respective tubes. In a preferredoption, a main spring urges the spreading element toward the distal endsof the occluding elements into an occluding position. The spreadingelement may be moved against the biasing force of the main spring into anon-occluding position near the proximal ends of the occluding elementseither manually through a button and linkage assembly coupled to thespreading element, or by control of a controller activating an actuatorthat is also coupled to the spreading element. A hinged door may beconfigured to cover the occluding elements and their respective sectionsof tubing. Activation of the actuator may be prevented if the door isnot properly closed over the occluding elements. Optionally, a retentionelement to hold the spreading element in a non-occluding position may beenabled when the door is in an open position. Enabling the retentionelement allows the spreader to be held in a non-occluding positionwithout continued application of force by a user on the button or bycontinued activation of the actuator. The retention element may bedisabled when the door is closed, so that the spreading element may befree to be moved into and out of an occluding position, either manuallyor via the actuator.

FIGS. 1 and 2 show exploded, perspective views of an occlusion assembly700 in accordance with an embodiment of the present disclosure. FIG. 1shows an exploded, perspective view of the occlusion assembly 700 from afront angle and FIG. 2 shows an exploded, perspective view of theocclusion assembly 700 from a back angle.

The occlusion assembly 700 receives a pair of tubes 705 and isconfigured to occlude the tubes 705 using a pinching action atapproximately the same level along the length of assembly 700. Thepinching action reduces the size of an inner fluid pathway of each tube705 to restrict the flow of fluid therethrough. The occlusion assembly700 may be used with an infusion pump, in a dialysis machine, inhemodialysis, in peritoneal dialysis, in hemofiltration, inhemodiafiltration, in intestinal dialysis, and the like.

The occlusion assembly 700 includes a frame 701. In some embodiments,the frame 701 includes tabs or snaps 709 for securing the frame tocorresponding slots on a front panel of a blood filtration device, suchas a hemodialysis apparatus.

The frame 701 includes anvils or blocks 702 and 703 against which a tube705 is compressed by the occluding ends 713 of a pair of occluding arms710 and 711, and a tube guide 704 to position each tube 705 againstblocks 702 and 703. The tube guide 704 and blocks 702 and 703 areconfigured to each position a tube 705 in a predetermined positionadjacent to each of the blocks 702 and 703. The occlusion assembly 700also includes a door 706 which is pivotally mounted to the frame 701.The door 706 can shut against the frame 701 to secure the tubes 705between each of the blocks 702 and 703 and the tube guide 704. The door706 includes a latch 707, which may be co-molded with or otherwiseattached to the door 706 via a hinge, such as for example a resilient,flexible base portion (e.g., via a living hinge) 708 to secure the door706 to the frame 701 in a closed position. As shown in FIGS. 1, 3, and4, a latch 707 may be pressed laterally to release a catch 740 fromengagement with a corresponding slot 741 on frame 701 to open the door706.

The occlusion assembly 700 includes two arms 710 and 711. The first arm710 includes a pivoting end 712 and an occluding end 713; likewise, thesecond arm 711 includes a pivoting end 714 and an occluding end 715. Thetwo arms 710 and 711 operate together to occlude the tubes 705 when amanual actuator, such as button 716, is released (or in otherembodiments engaged) and door 706 is closed, or when an actuator 717 isdeactivated

FIG. 3 shows a front, perspective view of the occlusion assembly 700with the door 706 open and the button 716 pressed to illustrate releaseof occluding arms 710 and 711 to permit loading and unloading of thetubes 705 in accordance with an embodiment of the present disclosure.FIG. 5 shows the front of the occlusion assembly 700 of FIG. 1 withoutthe door 706 and frame 701 to illustrate the arms 710 and 711 fullyoccluding the tubes 705 a, b in accordance with an embodiment of thepresent disclosure. As shown in FIG. 5, a wedge element or spreader 722contacts the facing sides of occluding arms 710 and 711, which underspring force can apply pressure to occluding arms 710 and 711 to pressthe occluding ends 713 and 715 of occluding arms 710 and 711 against aportion of tubes 705 a, b. A user may release the occluding arms 710 and711 by pressing button 716, which causes spreader 722 to withdraw awayfrom occluding arms 710 and 711, releasing the pressure of spreader 722being applied to the distal ends of occluding arms 710 and 711. In someaspects, the manual actuator (e.g. button 716) acts as an overridemechanism to an automated actuator (such as, for example, apneumatically operated piston/cylinder apparatus) connected to a tubingoccluder element (e.g., the spreader 722). The manual actuator isoperatively coupled to the tubing occluder to cause essentially linearmotion of at least a portion of the tubing occluder, moving theoccluding member from an occluding position to a non-occluding positionupon manual operation of the override mechanism by a user.

Similarly, activation of an actuator may release occluding arms 710 and711 by causing spreader 722 to withdraw away from the occluding ends713, 715 of occluding arms 710 and 714. In one embodiment, as shown inFIG. 1, spreader 722 may be formed of, co-molded with, attached to orconnected to a carriage assembly 723, which in turn is connected to anactuating arm of the actuator (see, e.g., FIGS. 7-9). The actuator maycomprise, for example, a motor and gear assembly (e.g., rack and pinionassembly or worm-type gear assembly), a solenoid, a hydraulic cylinderor a pneumatic cylinder, among others. In a preferred embodiment, theactuator comprises a pneumatic cylinder 717 that causes an actuating armcomprising a piston arm 742 to extend linearly against a spring force(which in an embodiment may be a coil spring 745 within cylinder 717 asshown in FIG. 11). As shown in FIG. 11, in a perspective side view of apneumatically operated linear actuator 717, piston arm 742 is connectedto carriage 723. When activated by pneumatic pressure, actuator 717extends piston arm 742 and moves carriage 723 and attached spreader 722in a direction that withdraws spreader 722 from engagement with thedistal ends 713, 715 of the occluding arms 710 and 711. (For clarity,occluding arm 711, frame 701, door 706, block 703 and tube guide 704,among other elements, have been removed from FIGS. 9-11). Preferably, amain spring that is either external or internal to cylinder/actuator 717may apply a biasing force to piston arm 742 or carriage 723 to causespreader 722 to move occluding arms 710 and 711 to an occludingposition. In the event of a loss of power or pneumatic pressure, theoccluding arms 710 and 711 will default to an occluding mode, preventingthe flow of fluid through tubes 705. As illustrated in a cross-sectionalview of occlusion assembly 700 in FIG. 11, in an embodiment, a coilspring 745 may be placed within the cylinder 743 to provide a biasingforce against which piston 744 may move piston arm 742 under pneumaticpressure. Pneumatic pressure may be supplied to linear actuator 717 froma pressure source (e.g., a tank pressurized by a pump) regulated by anintervening electromechanical valve under control of an electroniccontroller.

As shown in FIGS. 5 and 10, when the linear actuator 717 is fullyretracted, the carriage 723 carries spreader 722 along the facing sidesof the occluder arms 710 and 711 to rotate them into an occludingposition. The first arm 710 pivots about its pivoting end 712 to causethe occluding end 713 to press against first tube 705 a that isrestrained by block 702 (see FIG. 5). The second arm 711 pivots aboutits pivoting end 714 such that the occluding end 715 can press againstsecond tube 705 b which is restrained by block 703.

FIGS. 6 and 9 show occlusion assembly 700 in a non-occluding state(frame 701, door 706, blocks 702, 703, and other elements removed forclarity). When the button 716 is pressed or the linear actuator 717 isactivated, the carriage 723 and attached spreader 722 move distally awayfrom the actuator 717, allowing occluder arms 710 and 711 to rotateabout pivot points 712 and 714 into a non-occluding position. Theelastic resilience of the tubes 705 a.b may cause the arms 710 and 711to pivot towards each other. In some embodiments of the presentdisclosure, small magnets (not explicitly shown) embedded in the arms710 and 711 pull the arms 710 and 711 towards each other to facilitatethe retraction of the occluding ends 713 and 715 away from the tubes705. In other embodiments, small springs (not shown) may bias occludingarms 710 and 711 to pivot toward each other, the spring constants beingweak enough to be overcome by the main spring (e.g., spring 745) biasingcarriage 723 or spreader 722 into retracted (occluding) positions.

FIG. 4 shows a perspective side view of the occlusion assembly 700 ofFIG. 1 (frame 701 removed for clarity) showing the door 706 engaging aswitch 720 when the door 706 is closed in accordance with an embodimentof the present disclosure. As shown in FIG. 4, the hinge portion 708 oflatch 707 is coupled to an engagement member or catch 740 that can snapinto a cooperating slot 741 of the frame 701 (see, e.g., FIGS. 1 and 3).As the door 706 is closed, a portion of the catch 740 of latch 707 ofthe door 706 engages a spring-loaded switch 720, which in an embodimentincludes a spring arm 737 of the switch 720.

Engagement of switch 720 by closure of door 706 signals an electroniccontroller (not shown) that the door 706 is properly closed, and thatlinear actuator 717 may be activated to release occluders 710 and 711 toallow fluid to flow through tubes 705. The door 706 closure signal mayalso cause the controller to perform other functions, such as, forexample, instructing a pump coupled to the tubes 705 to begin pumpingfluid within tubes 705.

FIG. 7 shows the back of the occlusion assembly 700 of FIG. 1 with thelinear actuator 717 in a fully retracted position (i.e., in theoccluding position) in accordance with an embodiment of the presentdisclosure. FIG. 7 shows the back side of the occlusion assembly 700 inthe same configuration as shown for the front view of occlusion assembly700 in FIG. 5. FIG. 7 shows several working parts of the occlusionassembly 700 of FIG. 1 to illustrate the operation of the actuator 717and carriage 723 in accordance with an embodiment of the presentdisclosure. The carriage 723 moves with the extension or retraction ofthe piston arm 742 or with the actuation of the button 716. The carriage723 includes guides 724 attached to or co-molded with the carriage 723.The guides 724 guide the carriage 723 as it moves via actuation of thepiston arm 742 or with the actuation of the button 716. The guides 724interface with tracks 725 of the frame 701 (see, e.g., FIG. 2).

In an optional embodiment, when door 706 is open, actuation of button716 by a user or activation of actuator 717 by a controller causescarriage 723 and spreader 722 to move into a non-occluding position, anda retaining element or assembly allows the non-occluding position to beheld without further force being applied either by the user or by theactuator 717. In an exemplary embodiment shown in FIG. 7, the carriage723 may incorporate a latching pin 726 to cooperate with a slot or holein a retention member 718. The retention member 718 includes a surface727 positioned to be contacted by pins 738 located on the inside of door706 when it is closed (see, e.g., FIGS. 2 and 3). Through holes 739(see, e.g. FIGS. 1 and 3) allow pins 738 to contact a portion ofretention member 718 to displace it in a rearward direction. In theillustrated embodiment, pins 738 contact front plate 727 of retentionmember 718. Retention member 718 also includes a surface having a slotor hole 729 positioned to receive the head of a latching pin 726, whichin the illustrated embodiment comprises a horizontal plate 728 defininga receiving portion 729. Retention member 718 is arranged to slidewithin grooves or guides of the frame 701 (not shown) in response tocontact by the pins 738 when the door 706 is closed or opened (see, e.g.FIG. 2). A spring 730 mounted on the frame 701 may be biased to urge theretention member 718 forward to a stop feature (not shown) on the frame701 so that opening the door 706 allows the retention member 718 toslide forward, re-aligning the receiving portion 729 in relation to thelatching pin 726. When the door 706 is closed (see FIG. 1 or 2), thepins 738 on the door 706 press against the front plate 727 whichcompresses the spring 730 such that the receiving portion 729 of thehorizontal plate 728 is positioned directly over the latching pin 726.Upon alignment of the receiving portion 729 with the latching pin 726,the area of the receiving portion 729 is large enough to allow thelatching pin 726 to be released by the retention member 718, therebyallowing the carriage 723 to be subject to the spring force of the mainspring 745 in the actuator 717. If pneumatic pressure is not then beingapplied to the actuator 717, the carriage 723 is then free to move intoan occluding position. The retention member 718 in the disabled state(i.e., inoperative state) allows the latching pin 726 to move freelythrough the receiving portion 729 as the carriage 723 moves between thefully extended position and the fully retracted position.

FIG. 8 is a rear view of the occlusion assembly 700 with the actuator717 activated, and the piston arm 742 in an extended position to placethe occluding arms 710, 711 in a non-occluding state. In this view, thehead of the latching pin 726 is noted to be above the plane of thehorizontal plate 728 of the retention member 718, and the recessedregion 731 of the latching pin 726 is noted to be aligned with thereceiving portion 729 of the retention member 718. In this illustration,door 706 is in a closed position, implying that the receiving portion729 is in a sufficiently rearward position to prevent the latching pin726 from being latched into the retention member 718.

When the door 706 is sufficiently opened, the pins 738 of the door 706do not press against the front plate 727 and the spring 730 applies aforce on the front plate 727 such that the receiving portion 729 of theretention member 718 is positioned to allow the latching pin 726 toengage an edge of the receiving portion 729 and latch to the retentionmember 718. The latching pin 726 moves into the receiving portion 729pulling the front plate 727 rearward against the force of the spring 730when the receiving portion 729 is positioned to latch to the latchingpin 726. When the head of latching pin 726 moves sufficiently throughthe receiving portion 729, a recessed region 731 below the head oflatching pin 726 becomes co-aligned with the horizontal plate 728 whichmoves as the edge of the receiving portion 729 moves into the recessedregion 731 under the force of the spring 730 as applied to the frontplate 727. When the pins 738 of the door 706 sufficiently engage thefront plate 727, the receiving portion 729 is positioned to release thelatching pin 726 from the latch 718. Thus, when the door 706 is open,the carriage 723 and spreader 722 can be held in a non-occludingposition without the continuous application of force by the actuator 717or by a user pressing against the button 716. This permits a user toload and unload tubing from occlusion assembly 700 withoutsimultaneously having to apply force on the button 716. However, uponthe closing of the door 706, the retention member 718 is no longeroperative, and in the absence of continued application of force byeither the actuator 717 or through the button 716, the carriage 723 andspreader 722 will move into a position to cause the occluding arms 710and 711 to rotate to an occluding position.

FIGS. 9 and 10 show a side perspective view of several working parts ofthe occlusion assembly 700 of FIG. 1, with frame 701, blocks 702, 703,tube guide 704, door 706, occluding arm 711 and other parts removed forclarity. In FIG. 9, the piston arm 742 is fully extended in accordancewith an embodiment of the present disclosure. FIG. 9 shows the latchingpin 726 latched onto the retention member 718. That is, assuming thatdoor 706 is in an open position, the horizontal plate 728 is positionedby the force of spring 730 to engage the recessed region 731 of thelatching pin 726.

FIG. 10 shows a side, perspective view of the occlusion assembly 700 ofFIG. 1 with the piston arm 742 in a fully retracted position, withcertain elements removed as in FIG. 9 for clarity. In this example, thelatching pin 726 is shown to be completely disengaged from the retentionmember 718; and in the absence of an activating force on the actuator717 or a pressing force on the button 716, the piston arm 742, carriage723 and spreader 722 are free to retract under the force of a mainspring 745 (see FIG. 11) biased against the extension of piston arm 742.The spreader 722 then moves toward the occluding ends 713, 715 of theoccluding arms 710, 711. In an embodiment, as shown in FIGS. 9 and 10,the button 716 pivots about a pivot 732 to raise a lever arm 733 whenthe button 716 is pressed. The lever arm 733 is pivotally connected to aconnecting member 734 via a proximal pivot 735. The connecting member734 in turn is pivotally connected to the carriage 723 via a distalpivot 736. When the button 716 is pressed or the piston arm 742 movesthe carriage 723 toward the retention member 718, the connecting member734 moves with the carriage 723, rotating the button 716 about the pivot732 as shown in FIG. 9.

FIG. 12 shows the occlusion assembly 700 of FIG. 1 used in a front-panelassembly 911 of a dialysis system in accordance with an embodiment ofthe present disclosure. The occlusion assembly 700 occludes flexibletubes 901, 902 through which blood flows to and from a patient. Theright side tube 902 carries blood from a patient into a blood pumpassembly 1000 and the left side tube 901 carries blood from a dialyzer14 back to the patient after passing through an air trap 19. Theocclusion assembly 700 can occlude the flow of blood through both ofthese patient tubes 801, 802 simultaneously.

The tubes 901, 902 are connected to a blood pump cassette or assembly1000. The blood pump cassette 1000 is a modular unit that may be mountedonto and dismounted from the front-panel assembly 911. Both of thepatient tubes 901, 902 may be provided as an assembly with the bloodpump cassette 1000 and air trap 19, and may be loaded into the occlusionassembly 700 when the blood-pump cassette 1000 is mounted onto thefront-panel assembly 911. In this embodiment, the occlusion assembly 700forms a permanent part of the front panel assembly 911.

When the occlusion assembly 700 is in the non-occluding state, pumpslocated on blood pump cassette 1000 may be activated to pump blood froma patient through the right tube 902, up through the blood pumps andthrough a dialyzer 14. Blood processed by the dialyzer 14 then returnsto the patient via tube 901 after first passing through an air trap 19and an air-in-line detector 823.

While several embodiments of the invention have been described andillustrated herein, those of ordinary skill in the art will readilyenvision a variety of other means and structures for performing thefunctions and/or obtaining the results or advantages described herein,and each of such variations, modifications and improvements is deemed tobe within the scope of the present invention. More generally, thoseskilled in the art would readily appreciate that all parameters,dimensions, materials, and configurations described herein are meant tobe exemplary and that actual parameters, dimensions, materials, andconfigurations will depend upon specific applications for which theteachings of the present invention are used. Those skilled in the artwill recognize, or be able to ascertain using no more than routineexperimentation, many equivalents to the specific embodiments of theinvention described herein. It is, therefore, to be understood that theforegoing embodiments are presented by way of example only and that,within the scope of the appended claims and equivalents thereto, theinvention may be practiced otherwise than as specifically described. Thepresent invention is directed to each individual feature, system,material and/or method described herein. In addition, any combination oftwo or more such features, systems, materials and/or methods, providedthat such features, systems, materials and/or methods are not mutuallyinconsistent, is included within the scope of the present invention.

What is claimed:
 1. An occlusion assembly for occluding at least onecollapsible tube of a medical infusion device, comprising: a framecomprising a tubing guide configured for positioning the at least onecollapsible tube; a tubing occluder mounted to the frame and comprisingan occluding member constructed and positioned to controllably occludeor release occlusion of the at least one collapsible tube; a doorhingeably mounted to the frame and positioned to cover at least aportion of the at least one collapsible tube and the tubing occluderwhen in a closed position and to provide user access to the at least onecollapsible tube when in an open position; and a retaining memberengaged by the door when the door is in the closed position andconfigured to allow operation of the tubing occluder to occlude orrelease occlusion of the at least one collapsible tube when engaged bythe door in the closed position, and configured to hold the tubingoccluder in a non-occluding position when the door is moved from theclosed position to the open position while the tubing occluder is in thenon-occluding position.
 2. The occlusion assembly of claim 1, whereinthe tubing occluder comprises a carriage assembly slidably mounted tothe frame, and wherein the carriage assembly i. is operatively coupledto an actuator that is configured to cause sliding motion of thecarriage assembly, ii. is operatively coupled to an occluding memberengaging element configured to move the occluding member into anoccluding position or permit the occluding member to move into thenon-occluding position upon sliding motion of the carriage assembly, andiii. comprises a latching pin.
 3. The occlusion assembly of claim 2,wherein the retaining member is movably mounted to the frame, theretaining member comprising a surface configured and positioned to beengaged by a portion of the door when the door is in the closedposition, the retaining member further comprising a latching pinreceiving hole sized and positioned to allow substantially unrestrictedentry of the latching pin into the latching pin receiving hole uponsliding motion of the carriage assembly in a direction to permit theoccluding member to move into the non-occluding position and exit of thelatching pin from the latching pin receiving hole upon sliding motion ofthe carriage assembly in a direction to move the occluding member intothe occluding position when the door is in the closed position, whereinthe retaining member is biased for movement upon opening of the door tocause the latching pin receiving hole to move into engaging andretaining contact with the latching pin when the carriage assembly ispositioned to place the occluding member in its non-occluding positionwhen the door is in the open position.
 4. The occlusion assembly ofclaim 1, wherein the door comprises one or more contact elements on aportion of the door facing the retaining member when the door is in theclosed position, and wherein the retaining member comprises a contactsurface arranged to interact with the one or more contact elements ofthe door when the door is moved from the open position to the closedposition.
 5. The occlusion assembly of claim 4, wherein the retainingmember comprises a retainer spring biased to apply a force against thecontact surface of the retaining member, and against the door via theone or more contact elements when the door is in the closed position. 6.The occlusion assembly of claim 5, wherein the retaining member isconfigured to move to a non-retaining position when the door is moved tothe closed position and to move to a retaining position under force ofthe retainer spring when the door is moved to the open position.
 7. Theocclusion assembly of claim 6, wherein the tubing occluder comprises alatching pin with a head portion and a narrower neck portion, and theretaining member comprises a longitudinal plate defining a slot, thehead portion of the latching pin configured to be captured by the slotof the retaining member when the door is in the open position and thetubing occluder is moved from an occluding position to the non-occludingposition.
 8. The occlusion assembly of claim 7, wherein the retainingmember comprises a face plate perpendicular to the longitudinal plate,and wherein the retainer spring is positioned to apply a force againstthe face plate, wherein the slot of the retaining member includes areceiving portion sufficiently wide to receive the head portion of thelatching pin and comprises a retaining portion narrower than thereceiving portion and configured to receive the neck portion of thelatching pin, and wherein the receiving portion is aligned with thelatching pin when the door is in the closed position, and the retainingportion is aligned with the latching pin when the door is in the openposition.
 9. The occlusion assembly of claim 8, further comprising amanual actuator configured for operation by a user, the manual actuatorarranged to move the tubing occluder to the non-occluding position andto move the latching pin through the receiving portion of the retainingmember when the door is in the closed position, wherein opening the doorwhile the user operates the manual actuator causes the head portion ofthe latching pin to be captured by the slot of the retaining member,allowing the tubing occluder to remain in the non-occluding positionafter release of the manual actuator by the user.
 10. The occlusionassembly of claim 9, wherein the manual actuator comprises a push buttonadjacent the door and operable by the user when the door is in theclosed position.
 11. The occlusion assembly of claim 9, comprising apneumatic actuator coupled to the tubing occluder, the pneumaticactuator coupled to an actuator spring biased to place the tubingoccluder in the occluding position when the pneumatic actuator is notactuated, wherein actuation of the pneumatic actuator places the tubingoccluder in the non-occluding position.
 12. The occlusion assembly ofclaim 11, wherein the manual actuator and the actuator spring arearranged to allow the user to manually override a biasing force of theactuator spring to place the tubing occluder in the non-occludingposition.
 13. The occlusion assembly of claim 1, further comprising: atleast one actuator operatively coupled to the tubing occluder to causethe occluding member of the tubing occluder to move from an occludingposition to the non-occluding position.
 14. The occlusion assembly ofclaim 13, wherein the at least one collapsible tube comprises a firstcollapsible tube and a second collapsible tube, wherein the occludingmember of the tubing occluder is a first occluding member and the tubingoccluder further comprises a second occluding member, wherein theocclusion assembly is configured for occluding the first collapsibletube and the second collapsible tube, and wherein the tubing occluder isconstructed and positioned with respect to the first collapsible tubeand the second collapsible tube so that: the first occluding member ispositioned adjacent to the first collapsible tube, and the secondoccluding member is positioned adjacent to the second collapsible tube,when the first collapsible tube and the second collapsible tube areinstalled in the occlusion assembly for operation; and so that the firstoccluding member and the second occluding member are further positionedadjacent to each other such that a space is defined between the firstoccluding member and the second occluding member, the space being on aside of the first occluding member that is opposite to a side of thefirst occluding member that is adjacent to the first collapsible tube,and the space being on a side of the second occluding member that isopposite to a side of the second occluding member that is adjacent tothe second collapsible tube; and wherein the occlusion assembly furthercomprises: a spreader positioned within the space and movable within thespace from a first position to a second position, wherein movement fromthe first position to the second position causes the spreader to forceat least a portion of the first and second occluding members to moveapart from each other to increase size of the space and to force atube-contacting portion of each occluding member against the therespective first or second collapsible tube to which it is adjacent. 15.The occlusion assembly of claim 14, wherein the spreader is wedge shapedand coupled to the at least one actuator, and wherein the at least oneactuator causes the spreader to move in an essentially linear path fromthe first position to the second position to engage with the first andsecond occluding members and move them apart from each other.
 16. Theocclusion assembly of claim 15, wherein the first occluding membercomprises a first occluder arm and the second occluding member comprisesa second occluder arm, with each of the first occluder arm and thesecond occluder arm having a proximal end pivotally mounted to the frameand a distal end comprising a tube contacting surface, and whereinmovement of the spreader by the at least one actuator causes each of thefirst occluder arm and the second occluder arm to pivot such that thetube contacting surface of the first occluder arm moves apart from thetube contacting surface of the second occluder arm such that each tubecontacting surface compresses and occludes the respective first orsecond collapsible tube to which it is adjacent.
 17. The occlusionassembly of claim 16, wherein the occlusion assembly is configured sothat the first collapsible tube and the second collapsible tube areoccluded in an absence of a force applied by the at least one actuatorto cause release of occlusion.
 18. The occlusion assembly of claim 17,wherein the at least one actuator comprises a biasing element configuredto provide a restoring force causing occlusion of the first collapsibletube and the second collapsible tube in an absence of positive actuationof the at least one actuator to overcome the restoring force and releaseocclusion of the first collapsible tube and the second collapsible tube.19. The occlusion assembly of claim 13, wherein the at least oneactuator is pneumatically powered.
 20. The occlusion assembly of claim1, wherein the occlusion assembly comprises a portion of a fluidhandling assembly of a dialysis system.
 21. The occlusion assembly ofclaim 1, wherein the occlusion assembly further comprises at least onecollapsible tube mounted thereto.